2. Fundamental Process Of Tumor Growth Explained. As reported in ScienceDaily (Mar. 13, 2008), two papers appearing in the March 13 issue of the journal Nature help explaine the observation by Otto Warburg nearly 80 years ago that cancer cells perform energy metabolism in a way different from normal adult cells. The metabolic process known as the Warburg effect is essential for tumors' rapid growth; and they identify the M2 form of pyruvate kinase (PKM2), an enzyme involved in sugar metabolism, as an important mechanism behind this process.
3.The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth. This study shows that a single switch in a splice isoform of the glycolytic enzyme pyruvate kinase is necessary for the shift in cellular metabolism to aerobic glycolysis and that this promotes tumorigenesis. Tumour cells have been shown to express exclusively the embryonic M2 isoform of pyruvate kinase.
4. The Prime Cause and Prevention of Disease. It is found that the prime cause of cancer is the replacement of the respiration of oxygen ... in normal body cells by fermentation of sugar.
5. New Protein That Triggers Breast Cancer Identified. As reported by ScienceDaily (Jan. 14, 2009), Canadian researchers have identified a new protein in the progression of breast cancer. The protein ARF1 plays a critical role in cancer cell growth and the spread of tumours.